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產(chǎn)品規(guī)格
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BN41564R-50ul
50ul
￥1486.00
交叉反應：Human,Mouse,Rat(predicted:Pig,Cow,Rabbit,Sheep) 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt
BN41564R-100ul
100ul
￥2360.00
交叉反應：Human,Mouse,Rat(predicted:Pig,Cow,Rabbit,Sheep) 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt
BN41564R-200ul
200ul
￥3490.00
交叉反應：Human,Mouse,Rat(predicted:Pig,Cow,Rabbit,Sheep) 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt
產(chǎn)品描述
| 英文名稱 | Aquaporin 4 |
| 中文名稱 | 水通道蛋白4抗體 |
| 別 名 | aquaporin 4; WCH4; Mercurial-insensitive water channel; MIWC; AQP 4; AQP4; Aquaporin4; HMIWC 2; HMIWC2; Mercurial insensitive water channel; MGC22454; MIWC; AQP4_HUMAN; Aquaporin-4; AQP-4. |
| 研究領域 | 腫瘤 信號轉導 通道蛋白 新陳代謝 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Human, Mouse, Rat, (predicted: Pig, Cow, Rabbit, Sheep, ) |
| 產(chǎn)品應用 | WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg /test ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 36kDa |
| 細胞定位 | 細胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human AQP4:271-323/323 <Cytoplasmic> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The encoded protein is the predominant aquaporin found in brain. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system. Subunit: Homotetramer. Part of a complex containing MLC1, TRPV4, HEPACAM and ATP1B1. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Brain, muscle, heart, kidney, lung, and trachea. Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family. SWISS: P55088 Gene ID: 361 Database links: Entrez Gene: 361 Human Entrez Gene: 11829 Mouse Omim: 600308 Human SwissProt: P55087 Human SwissProt: P55088 Mouse Unigene: 281008 Cow Unigene: 315369 Human Unigene: 250786 Mouse Unigene: 90091 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 通道蛋白（Channel Protein） 水通道蛋白(AQPs)廣泛分布于機體不同組織器官中,腦組織中的水通道蛋白主要為AQP4. AQP-4蛋白主要在星型膠質細胞和室管膜細胞內表達,尤其在于毛細血管和軟腦膜直接接觸的膠質細胞上及血管周表達豐富. 水通道蛋白4的分布特點與其功能密切相關,可能是腦脊液重吸收、滲透壓調節(jié)、腦水腫形成等生理、病理過程的分子生物學基礎.研究水通道蛋白4可為腦水腫及水代謝疾病提供分子水平的理論依據(jù),同時為臨床治療腦水腫及水代謝疾病提供一種新途徑. |
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